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Walter N Hittelman Selected Research

BLyS receptor

9/2012Bax345/BLyS: a novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin.
2/2007The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.

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Walter N Hittelman Research Topics

Disease

38Neoplasms (Cancer)
01/2021 - 05/2002
5Breast Neoplasms (Breast Cancer)
11/2014 - 02/2006
4Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2021 - 02/2007
4Squamous Cell Carcinoma of Head and Neck
01/2019 - 05/2002
4Melanoma (Melanoma, Malignant)
07/2013 - 01/2006
4Carcinogenesis
01/2007 - 02/2003
4Esophageal Neoplasms (Esophageal Cancer)
12/2006 - 02/2006
4Neoplasm Metastasis (Metastasis)
11/2006 - 12/2005
3Chromosome Aberrations (Chromosome Abnormalities)
12/2019 - 07/2004
2Mouth Neoplasms (Oral Cancer)
01/2019 - 11/2017
2Hypersensitivity (Allergy)
01/2018 - 06/2015
2Neuralgia (Stump Neuralgia)
01/2016 - 06/2015
2Ovarian Neoplasms (Ovarian Cancer)
04/2014 - 01/2003
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
09/2012 - 02/2007
2Hyperplasia
08/2011 - 04/2005
2Hypoxia (Hypoxemia)
10/2010 - 09/2009
2Genomic Instability
02/2007 - 04/2003
2Adenocarcinoma
02/2007 - 12/2005
2Carcinoma (Carcinomatosis)
11/2006 - 02/2006
2Chromosomal Instability (Chromosome Stability)
12/2005 - 05/2005
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2021
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2016
1Pain (Aches)
06/2015
1Necrosis
04/2013
1Mitochondrial Diseases (Mitochondrial Disease)
09/2012
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
08/2012
1Peripheral Nervous System Diseases (PNS Diseases)
05/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
05/2012
1Hyperalgesia
05/2012

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
01/2020 - 04/2003
6DNA (Deoxyribonucleic Acid)IBA
12/2019 - 07/2004
5Biomarkers (Surrogate Marker)IBA
01/2018 - 09/2002
5Cyclin D1IBA
08/2011 - 02/2003
4Pharmaceutical PreparationsIBA
12/2019 - 08/2006
4TWEAK ReceptorIBA
11/2014 - 07/2011
4Immunotoxins (Immunotoxin)IBA
07/2013 - 01/2012
3Phosphotransferases (Kinase)IBA
01/2021 - 02/2006
3Peptides (Polypeptides)IBA
04/2014 - 01/2012
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2011 - 02/2006
3LigandsIBA
08/2011 - 02/2007
3FenretinideIBA
01/2009 - 09/2002
2Immunoconjugates (Immunoconjugate)IBA
01/2020 - 07/2011
2Serine Proteases (Serine Protease)IBA
07/2019 - 10/2013
2Granzymes (Granzyme)IBA
07/2019 - 10/2013
2Small Interfering RNA (siRNA)IBA
06/2015 - 04/2003
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2014 - 08/2011
2Trastuzumab (Herceptin)FDA Link
07/2013 - 06/2013
2Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
04/2013 - 07/2011
2BLyS receptorIBA
09/2012 - 02/2007
2SurvivinIBA
09/2012 - 05/2005
2rGel-BLyS fusion toxinIBA
08/2012 - 02/2007
2Paclitaxel (Taxol)FDA LinkGeneric
05/2012 - 01/2003
2Gelonium multiflorum GEL proteinIBA
08/2011 - 02/2007
2AdenineFDA LinkGeneric
02/2007 - 05/2002
2NF-kappa B (NF-kB)IBA
11/2006 - 02/2006
2RetinoidsIBA
05/2006 - 02/2003
2retinamideIBA
05/2006 - 09/2002
270-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
02/2006 - 01/2003
2TOR Serine-Threonine KinasesIBA
02/2006 - 04/2005
1Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA
01/2021
1Protein Kinases (Protein Kinase)IBA
01/2021
1Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)IBA
01/2021
12'- cyano- 2'- deoxyarabinofuranosylcytosineIBA
12/2019
1Cisplatin (Platino)FDA LinkGeneric
01/2019
1ThiosemicarbazonesIBA
01/2019
1adavosertibIBA
11/2017
1VorinostatFDA Link
11/2017
1gamma-Aminobutyric Acid (GABA)IBA
01/2016
1Vincristine (Oncovin)FDA LinkGeneric
01/2016
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2016
1Pemetrexed (MTA)FDA Link
01/2016
1Taxoids (Taxanes)IBA
01/2016
1ChloridesIBA
01/2016
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2016
1Vinca AlkaloidsIBA
01/2016
1InflammasomesIBA
06/2015
1Hormones (Hormone)IBA
11/2014
1N- phenylacetoaminomethylene- DL- p- nitrophenylalanine (A 101)IBA
11/2014
1Messenger RNA (mRNA)IBA
11/2014
1Cytokine TWEAKIBA
11/2014
1ProlactinIBA
04/2014
1Lapatinib (GW572016)FDA Link
06/2013
1Indicators and Reagents (Reagents)IBA
04/2013
1Cell Surface ReceptorsIBA
04/2013
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2013
1Bortezomib (Velcade)FDA Link
08/2012
1Therapeutic UsesIBA
08/2012
1Antineoplastic Agents (Antineoplastics)IBA
05/2012
1CannabinoidsIBA
05/2012
1Single-Chain AntibodiesIBA
01/2012
1ErbB Receptors (EGF Receptor)IBA
08/2011
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
08/2011

Therapy/Procedure

12Therapeutics
01/2018 - 02/2003
4Drug Therapy (Chemotherapy)
01/2019 - 08/2006
3Chemoprevention
12/2005 - 09/2002
2Radiotherapy
09/2009 - 05/2002
1Cell- and Tissue-Based Therapy (Cell Therapy)
07/2019
1Spinal Injections
06/2015
1Intravenous Administration
06/2013